Title: Comparative study on adjusting liver and spleen prescription and tonifying liver and kidney prescription on erythrocyte immune and cytokines of adjuvant rats
Abstract: Objective:To explore adjusting liver and spleen prescription and tonifying liver and kidney prescription on erythrocyte immune and cytokines of adjuvant rats by observing the serum cytokines interleukin-4(IL-4),interferon-γ(IFN-γ)and the ratio and erythrocyte immune function.Methods:According to body weight,Wistar rats were randomly divided into normal group,model group,adjusting liver and spleen prescription group,tonifying liver and kidney pre-scription group,torch-gen-chip group,fenbid group.The autoimmune arthritis rats were induced by proinflammatory adjuvant method.The serum IL-4,IFN-γ were detected by ELISA method,and erythrocyte immune function were test-ed by RBC-C3b rosette and its receptors.Results:The serum IFN-γ/IL-4 ratio of the model group was significantly increased(P 0.01).RBC-C3b rosette receptor rate was significantly lower(P 0.01),RBC-IC rosette rate significantly increased(P 0.01).Each treating group could significantly improve these indexes,and the adjusting liver and spleen prescription group had the best effection to recover the ratio of IFN-γ/IL-4 to resume and to lower RBC-IC rosette rate.Conclusion:Adjusting liver and spleen prescription has significent effects on regulating cytokines and clearing away the harmful immune complexes of adjuvant rats.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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