Title: Relationship between renal blood flow and urinary enzymes in newborns with asphyxia
Abstract: Objective To study the relationship between change of renal blood flow and urinary enzymes in newborns with asphyxia.Methods Seventy-one asphyxiated neonates were enrolled in the study,and they were further divided into two groups(severe asphyxiated group and mild asphyxiated group),20 normal newborns were studied as controls.Levels of NAG,GAL,ALP,and GGT in the urine,and BUN,Cr levels in the blood were tested.Parameters of renal artery blood flow(PSFV,RI,EDFV,TAMX,and PI) were tested on the first,third day,and seventh day after birth.Results Urinary NAG,GAL,ALP and GGT were significantly higher in the asphyxiated newborns than those in the control group(P 0.05).NAG,GAL,ALP,and GGT were significantly higher in the severe asphyxiated group than those in the mild asphyxiated group(P 0.01).EDFV was significantly lower,while RI and PI were significantly higher in asphyxiated group than those in the control group on the first,third and seventh day(both P 0.05).EDFV was negatively correlated with NAG,GAL,ALP,and GGT(P 0.01).However,RI and PI were positively correlated with NAG,GAL,ALP,and GGT(P 0.01).Conclusions Testing renal blood flow is time-saving and convenient.Compared with urinary enzyme examination,it is less affected by external factors and can be monitored continuously.The levels of urinary enzymes can be estimated by testing the renal blood flow.Similarly,levels of urinary enzymes can reflect the status of renal blood flow,and to assess if the newborn has any renal vasospasm and/or renal ischemia.This will provide evidence for giving drugs to dilate the renal blood vessel.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot