Title: Drug resistance and distribution in common clinical Gram-negative bacilli collected from intensive care units
Abstract: Objectives To investigate drug resistance and distribution of Gram-negative bacilli in intensive care units(ICU) in our hospital, in order to provide guidance for clinical treatment. Methods WalkAway 96 PLUS automated microbial identification system was used for bacterial identification. Drug resistance and distribution of collected Gram-negative bacilli in ICU were analyzed by Microdilution method and K-B method. Results Total of 1329 strains of Gram-negative bacilli were collected from ICU in our hospital during June 2010 to April 2011, in which the top five of isolation rates were Pseudomonas aeruginosa (263 strains, 19.8%), Acinetobacter baumannii (204 strains, 15.3%), Klebsiella pneumoniae (166 strains, 12.5%), Stenotrophomonas maltophilia(69 strains, 5.2%), and Escherichia coli (58 strains, 4.4%). Escherichia coli were mainly collected from sputum (34.5%), blood (31.0%) and urine (27.6%). The other bacteria were mainly collected from sputum (86.7%-92.8%). Resistance rates of Klebsiella pneumoniae and Escherichia coli to imipenem were 2.4% and 0, and 14.5% and 15.5% to piperacillin/tazobactam; and 19%-100% to levofloxacin, ciprofloxacin, amikacin, cefepime, cidomycin, tobramycin, cefotaxime, aztreonam, SMZ-TMP, amoxicillin/clavulanic, cefoxitin, cefazolin and ampicillin. In non-fermenting gram-negative bacteria, resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannii to amikacin, levofloxacin, ciprofloxacin, cefepime, ceftazidime, cidomycin, tobramycin, imipenem, cefotaxime, SMZ-TMP and piperacillin/tazobactam were 44.9%-100%. Resistance rates of Stenotrophomonas maltophilia to SMZ-TMP and levofloxacin were 10.1% and 8.7%,respectively. Conclusions Resistance of Gram-negative bacilli collected from ICU should be monitored dynamicly in - hospital. Antibiotics should be chosen according to drug sensitivity test in clinical practice to prevent the spread of epidemic resistant strains.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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