Title: Drug resistance of clinic isolates in intensive care unit
Abstract: Objective To investigate the changes of distribution and drug resistance among the clinic isolates from intensive care unit(ICU).Methods All the pathogens isolated from ICU were retrospectively analyzed.Results The total number of clinical isolates increased in years,and the isolates of Gram-negative bacilli increased from 250 in 2008 up to 316 in 2010 and accounted for 65.2%.The three most common encountered Gram-negative bacilli in 2008 were Pseudomonas aeruginosa(27.1%),Acinetobacter spp.(22.3%)and Staphylococcus aureus(11.6%),respectively,while those in 2010 were Acinetobacter spp(38.8%),Staphylococcus aureus(16.1%)and Pseudomonas aeruginosa(12.6%),respectively.The antibiotics resistance text showed that the main Gram-negative bacilli strains were all in multi-drug resistance.The common Gram-negative bacilli strains showed relatively low resistance to imipenem,cefoperazone/sulbactam,amikacin and levofloxacin.The resistant rate of imipenem was the lowest.Conclusion The isolated rate of Gram-negative bacilli in ICU increases.The condition of the drug-resistance is very serious.Imipenem and levofloxaxin have the strongest antibacterial activity against Acinetobacter spp.Imipenem and amikacin have the strongest antibacterial activity against Pseudomonas aeruginosa.Vancomycin,teicoplanin and doxycycline remained highly active against Gram-positive cocci.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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