Title: Analysis of the Gram-negative Bacilli Resistance of Nosocomial Infection in Intensive Care Unit
Abstract: Objective:To investigate the resistance rate of the Gram-negative bacilli of Nosocomail infection in ICU.Methods:563 strains of nosocomial pathogens were isolated from January1,1999 to December 31,2003 in ICU of our hospital. Antibiotic resistance was conducted and E test was performed to measure the MIC.Results:Nosocomial infection in intensive care unit was highest among gram-negative bacteria,espectically Pseudomonas aeruginosa(26.3%), Pseudomonas aeruginosa were the most prevalent isolates from ICU infections followed by Escherichia coil(18.1%), Klebsiella pneumoniae(15.0%), Entrobacter (14.6%), Acinetobacter spp(12.1%),Xanthomonas sp(9.8%).44% strain of Escherichia coil and 42% strain Klebsiella pneumoniae could produce extended-spectrum beta-lactamases(ESBLs). MIC90 for cefotaxime, ceftazidime, ciprofloxacin and imipenem against Pseudomonas aeruginosa was 256、256、32、6 mg/L. MIC90 for cefotaxime, ceftazidime, gentamicin and ciprofloxacin against Entrobacter, ESBLs producing strains of Escherichia coil and Klebsiella pneumoniae were 256、32~256、256、64 mg/L. They were cross-resistance.Conclusions:Antibiotics policy should be urgently needed in order to delay the resistance development.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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