Title: Application value of joint detection of tumor markers in assisted diagnosis of lung cancer
Abstract: Objective To explore the application value of joint detection of tumor markers in assisted diagnosis of lung cancer.Methods One hundred and five patients with lung cancer,98 with benign lung lesions and 86 healthy people in the same period were divided into lung cancer group,benign lesion group and control group,respectively.The levels of squamous cell carcinoma related antigen(SCC Ag),neuron specific enolase(NSE),cyto keratin 21-1(CYFRA21-1),carcinoma embryonic antigen(CEA)and carbohydrate antigen 125(CA125)in three groups were detected respectively.The difference among the detected results of tumor markers,and the sensitivity and specificity of single and joint detection were compared.Results Serum SCC Ag,NSE,CYFRA21-1,CEA and CA125 levelsin lung cancer group were evidently higher than those in other two groups.CA125(61.9%)had the highest sensitivity for detecting the lung cancer,followed by CEA(52.4%)and SCC Ag(9.5%).The sensitivity was the highest in the joint detection of four markers(87.6%),and the sensitivity of CA125+CEA+SCC Ag and CA125+CEA was the highest in the joint detection of three markers(85.7%)and two markers(77.1%),respectively.The specificity of both single and joint detection was above 90% with no significant differences.Conclusion Joint detection can remarkably improve the sensitivity in diagnosis of lung cancer,and has a certain clinical value in assisted diagnosis of lung cancer.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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