Title: Antagonistic effects of resveratrol on Parkinson’s disease model rats
Abstract: Objective To explore antagonistic effects of resveratrol on Parkinson’s disease (PD) model rats. Methods The PD model rats were induced by injecting 6-OHDA into the right striatum, The valid PD rats were randomly divided into four groups: model control group, resveratrol groups (10, 20 and 40 mg/kg/d), the VitE control group (50 mg/kg/d), sham group and normal administration group (resveratrol 20 mg/kg/d). Resveratrol was given orally once daily for 10 weeks, Rotational test was examined weekly during administration, then the activity of SOD, GSH-PX and level of MDA in injured brain tissues were detected respectively with chemical chromatometry. Results 1. Resveratrol can ameliorate significantly turns of rats. 2. Resveratrol can increase significantly the average activity of SOD, GSH-PX, and decrease obviousely the average level of MDA. Conclusion Resveratrol have obvious protective effect on PD model rats, which may be related to attenuate 6-OHDA-induced oxidative stress injury.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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