Title: Clinical significance of E-cad and #beta#-cat expressions in CIN and cervical squamous cell carcinoma
Abstract: OBJECTIVE:To study E-cad and β-catenin (β-cat) expressions and their clinical significance in cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma.METHODS:E-cad and β-cat expressions were investigated by the SP method in normal cervical epithelia,low-grade CIN, high-grade CIN and cervical squamous cell carcinoma.RESULTS:In normal cervical epithelia,E-cad and β-cat expressed at the membranes. E-cad membranous expression rates in normal cervical epithelia, CIN Ⅰ, CIN Ⅱ-Ⅲ and squamous cell carcinomas were 86%(12/14), 82%(9/11), 54%(7/13) and 21%(8/38), respectively; β-catmembranous expression rates were 79%(11/14), 64%(7/11), 23%(3/13) and 11%(4/38), respectively. The difference of E-cad expression between normal cervical epithelia and invasive squamous cell carcinoma was as statistically significant as that between CINⅠ and carcinoma,P0.05. The difference of E-cad expression in histological classification of invasive carcinoma was as statistically significant as that in depth of muscular invasion,P0.05.The difference of β-cat expression between normal cervical epithelia and CINⅡ-Ⅲ was as statistically significant as that between normal cervical epithelia and invasive squamous cell carcinoma,CINⅠ and carcinoma,P0.05.The differences of β-cat expression in histological classifications of invasive carcinoma were statistically significant,P0.05. The expression patterns between E-cad and β-cat in invasive carcinoma were correlated with each other, P0.05.CONCLUSIONS:The abnormal expressions of E-cad and β-cat are early events in the progress of carcinoma.In cervical squamous cell carcinoma,their abnormal expressions may be related to the invasion of carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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