Title: Relationship between acute myocardial infarction and oxidative stress in the aged
Abstract: Objective:To explore the relationship between acute myocardial infarction(AMI) and oxidative stress by detecting serum concentrations of advanced oxidation protein products(AOPP),malonaldehyde(MDA),superoxide dismutase(SOD),and oxidized low density lipoprotein(ox-LDL) in the aged.Methods: The serum concentration of AOPP was measured by spectrophotometer,MDA by thiobarbituric acid method,SOD activity by xanthine oxidase method,and ox-LDL by double antibody sandwich ELISA in 30 aged patients with AMI,27 aged patients with unstable angina(UA),and 36 healthy controls(HC).Results: Compared with HC group,serum levels of AOPP,MDA,SOD and ox-LDL in AMI group and UA group increased significantly(P 0.01 or P 0.05).There were significant differences in the serum concentrations of AOPP and ox-LDL between AMI group and UA group(P 0.05),while no difference in MDA content and SOD activity(P 0.05).In AMI group,all detected index of single-vessel-disease subgroup were higher than those of multiple-vessel-disease subgroup(P 0.05).Conclusion: An obvious oxidative stress reaction is happened in the onset of aged AMI,and is closely correlated with severity of disease.The change of AOPP and ox-LDL maybe has some diagnostic value for AMI in the aged.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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