Title: The role of serum uric acid as well as oxidative stress in the pathogenesis of coronary heart disease
Abstract: ObjectiveTo elucidate the effects on elevated serum uric acid(UA) level as well as oxidative stress damage in the pathogenesis of coronary heart disease(CHD) by exploring the level of serum UA and oxidative stress damage in CHD.MethodsTo select 30 patients with acute coronary syndrome(ACS),30 patients with stable angina pectoris(SAP) and 30 patients as controlled(CO) group,and the levels of serum UA,MDA and T-SOD activity were measured.ResultsThe levels of serum UA and MDA were higher,while T-SOD activity was lower in ACS and SAP group compared with CO group(P0.05);and the serum MDA level was higher in ACS group compared with SAP group(P0.05),while T-SOD activity was lower(P0.05) and there was no difference in the serum UA between two groups(P0.05).The serum UA level was positively correlated with MDA(r=0.614,P0.05),but negatively correlated with T-SOD activity(r=-0.591,P0.05)in CHD patients.Moreover,to SAP group,the serum level of T-SOD activity was lower in the higher serum UA patients compared with the normal serum UA patients(P0.05);To ACS group,the levels of MDA was higher(P0.05),while T-SOD activity was lower(P0.05)in the higher serum UA patients compared with the normal serum UA patients.ConclusionThe elevated serum UA is probably a risk factor of CHD and induces the pathogenesis and development of CHD by promoting the oxidative stress damage and the ability of anti-oxidation decline.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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