Title: The relationship between oxidized low density lipoprotein, malondialdehyde, total antioxidative capability and coronary atherosclerosis
Abstract: Objective To measure the levels of plasma(serum) oxidized low density lipoprotein(OX-LDL),malondialdehyde(MDA)and total antioxidative capability(TAOC) in patients with coronary atherosclerosis(AS) and study the relationship between the three indexes and AS. Methods The levels of plasma(serum) OX-LDL,MDA and TAOC were measured in 52 patients with AS and 30 controls by enzyme linked immunosorbent assay(ELISA), thiobarbiturates and Fe3+/Fe2+ chemistry method and the results compared with data of coronary angiography. Result The levels of OX-LDL and MDA in AS were markedly higher than controls(P0.05) and they also increased with the increasing extent of coronary stenosis and the numbers of diseased coronary vessels, The levels of TAOC were significantly lower than controls(P0.05) and it also declined with the increasing extent of coronary stenosis and the numbers of diseased coronary vessels, the levels of OX-LDL and MDA negatively correlated with the TAOC(r=-0.71, r=-0.67, P0.05). Conclusion The data suggests that the levels of plasma(serum) OX-LDL, MDA are associated with occurrence and progression of AS, measure the levels of serum TAOC can provide an important basis for treatment of antioxidative with AS.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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