Title: Neuroprotective effect of hyperbaric oxygen combined with anti-parkinson granule in treating Parkinson's disease rats
Abstract: Objective To explore the neuroprotective effect of hyperbaric oxygen (HBO) combined with anti -parkinson granule on Parkinson' s disease (PD) rats. Methods PD rat model was established by 6-OHDA. Model rats were randomly divided into 2 groups: model group(A) and treatment group( hyperbaric oxygen combined with anti -parkinson granule) ( B). The changes of the activities of SOD and GSH-Px, the content of MDA were determined by using immunohistochemistry and the changes of expression of TH、GFAP、Bcl-2 and Bax protein were determined by using immunohistochemistry in PD rats. Results The changes of ethology appeared obviously. The activities of SOD and GSH-Px significantly increased , and the content of MDA decreased in HBO group compared to model group (P 0.05). The activities of TH, Bcl-2 significantly increased , and the expression of GFAP、Bax protein content decreased in treatment groups compared with the model group (P 0. 01 or P 0. 05). Conclusion Hyperbaric oxygen combined with anti-parkinson granule can restrain the degree of oxidative stress, elevate its antioxidant abilities and significantly restrain apoptosis in substantia nigra. It is an effective neuroprotective and thempeutic measure for PD model rats.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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