Title: Therapeutic Effect of Nuanxin Capsule Prescribed by Professor Deng Tietao for Diastolic Heart Failure
Abstract: 【Objective】To observe the therapeutic effect of Nuanxin Capsule(NC) prescribed by Professor Deng Tietao for diastolic heart failure(DHF).【Methods】Eighty DHF patients were randomized into two groups.The two groups were given routine western medicines such as diuretics,vasodilators,angiotensin-converting enzyme inhibitor(ACEI),beta-receptor blocker and calcium antagonists.Group A(N=41)received NC(mainly composed of Radix Ginseng Rubra,Radix Aconiti Lateralis Preparata,Semen Coicis,Exocarpium Citri Rubrum,Radix Notoginseng),and group B(N=39)received placebo additionally.The treatment lasted 9 months.The total therapeutic effect,TCM syndrome scoring,cardiac function classification,walking distance within 6 min were evaluated,and the recurrence rate,mortality rate and adverse reaction were observed in the two groups after treatment.【Results】There were 2 patients in group A and 1 in group B loss of follow-up.In group A,10 patients were short-term cured,21 markedly effective,4 effective,4 ineffective and the total effective rate was 89.74%;In group B,7 patients were short-term cured,14 markedly effective,9 effective,8 ineffective and the total effective rate was 78.94%;the therapeutic effect in group A was better than that in group B(P0.05).Symptoms and signs of short breath,chest distress,palpitation,lassitude,edema of the limbs,anorexia,scanty urine,cyanotic lips were relieved in the two groups(P0.05),and group A has a better effect on relieving short breath,chest distress,anorexia,cyanotic lips(P0.05).The follow-up for 12 months showed that recurrence was found in 9 patients of group A and 17 of group B,death in 2 of group A and 7 of group B.The recurrence rate and mortality rate were 23.08% and 5.13% in group A respectively,and 44.73% and 18.42% in group B respectively.The differences of the recurrence rate and mortality rate between the two groups were significant(P0.05).The walking distance within 6 min was prolonged in the two groups,the effect in group A being better than that in group B(P0.05).Only one patient had skin rash in group B during treatment,and no adverse reaction was found in other patients.【Conclusion】NC has certain effect for DHF by relieving symptoms and signs,decreasing the recurrence rate and mortality rate,increase walking distance within 6 min.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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