Title: Investigation on the association between MTHFR gene C677T polymorphism and pre-eclampsia
Abstract: Objective To investigate the prevalence of methylene tetrahydrofolate reductase(MTHFR)gene C677T polymorphism and its association with pre-eclampsia in Shandong Hans.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)analysis was conducted to examine genotypes of 42 patients with pre-eclampsia and 64 health controls.The genotype frequencies were calculated by gene counting in patients and controls to ananalyze the association of MTHFR C677T polymorphism with pre-eclampsia.Results:In case-controls,the frequencies of C/T heterozygote were 45.24 % and 62.50%;whereas those of T/T homozygote were 40.48% and 17.19%.The raltive risk(OR)of individuals with the T/T genotype for pre-eclampsia was 3.276(95% confidence interval:1.339~8.02,P=0.008)compared with that of individuals with C/C and C/T genotype.Conclusion:The 677TT mutation of methylene tetrahydrofolate reductase gene is a risk factor associated with pre-eclampsia.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 7
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