Title: The study of the relationship of MTHFR polymorphisms with rheumatoid diseases
Abstract: Objective To assess the relationship of methylene tetrahydrofolate reductase(MTHFR)C677T genotypes to some rheumatoid diseases.Methods 54 cases with SLE,48 cases with RA,60 cases with AS,30 cases with uSpA and 62 controls were recruited into the study.Plasma Hcy,vitamin B12,folate were measured in all patients and controls.MTHFR gene C677T polymorphisms were detected by the technique of polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP).Results(1)CC genotype in each patient group was significantly lower than that in control group,the total mutant T allele frequency was significantly higher than that in control group.(2)The MTHFR gene mutation increased Hcy level dramatically[in CC,CT and TT genotype being(13.41±5.78),(16.81±4.22),(20.88±6.60)μmol·L-1,respectively,P0.05).(3)TT genotype was susceptible to hyperhomocysteinemia and SLE(OR=56.47,6.93;P0.05).Conclusions(1)MTHFR C677T gene mutation and hyperhomocysteinemia are found in most SLE,RA,AS and USPA patients.(2)TT genotype of MTHFR is susceptible to hyperhomocysteinemia and SLE.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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Cited By Count: 1
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