Title: The Relationship of Genetic Polymorphisms of N~ (5,10)-methylenetetrahydrofolateb Reductase Gene to Cerebral Vascular Disease
Abstract: Objectives To investigate the relationship of genetic polymorphisms of N 5,10-methylenetetrahydrofolateb reductase gene to cerebral vascular disease. Methods The polymorphisms of N 5,10-methylenetetrahydrofolateb reductase gene were analyzed in 107 patients and 78 healthy subjects with polymaerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results (1)There were significant differences in the frequencies of MTHFR 677C→T genotypes between two groups(P0.01). The frequencies of homozygous mutation (T/T) (22.4%) and heterozygous mutation(T/C)(61.7%) were higher in tested cases than in controls(T/T 19.0%,T/C 41.8%,respectively),but the later was statistically significant(P 0.05).The frequency of T alleles was also significantly higher in tested cases than in controls (53.3% and 39.4%, respectively, P0.01). (2)The risk is markedly high in cases with mutant and T alleles genotypes. The heterozygous genotypes had higher risk than other genotypes.Conclusions MTHFR677C→Tmutationmay be a risk factor for cerebral vascular disease.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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