Title: Experimental study on elevating survival rate of rat myocardial infarction model
Abstract: Objective To elevate the survival rate of rat myocardial infarction model through ameliorated experimental conditions.Methods Left anterior descending coronary arteries were ligated to induce myocardial infarction model in 80 Wistar rats and some details that may influence the survival rate of rat were regulated.The details included the mode of anaesthesia,trachea cannula,the operation and the location of ligating to the left anterior descending coronary.Results Some methods were demonstrated to improve the survival rate of rats remarkably.These methods included intraperitoneal injection of Choral hydrate(300mg/kg),trachea cannula with 16G vein needle,opening the breast at the right recumbent position,ligating the left anterior descending coronary artery under the attachment line between the left auricle and pulmonary conus.Conclusion The survival rate of rat myocardial infarction model can be apparently elevated by ameliorating some related experimental conditions.It could provide experimental basis for further research.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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