Title: Establishment of Rat Model of Myocardial Infarction
Abstract: Objective To discuss the method of establishment of myocardial infarction in rats.Methods SD rats were anaesthetized with 4% chloral hydrate.The left arrterior descending coronary artery(LAD) was ligated to form embolus.The embolus blcked the coronary blood blow and caused my-ocardial infarct.Thus,a pathologic and physiological course similar to clinical condition was developed.Results Twenty minutes after operation,SD rates’ ECG showed the ST segment elevated and the pathological Q wave appeared.Observing the histological section under the light microscope,it was found that pathological cardiac muscle cells were arranged in disorder,and cell nucleus pyknosis and chip occured.Conclusion The technique possesses the characteristic of being simple and that with light trauma and high success rate.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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