Title: Expression of vasculare endothelial growth factor and microvessel density in salivary adenoid cystic carcinoma
Abstract: Objective To investigate the expression of vasculare endothelial growth factor and microvessel density and their relations with the clinical pathological characters of salivary adenoid cystic carcinoma.Methods SP immunohistochemistry was applied to detect the expression of VEGF;microvessel density was counted by anti-CD34 antibody in 35 ACC cases,13 cases of pleomorphic adenoma,10 cases of normal salivary gland tissue.Results Positive expression rate of VEGF enhanced in normal salivary gland tissue,pleomorphic adenoma and ACC stepply(P 0.05) and so did the MVD counted(P 0.05);MVD tended to depend on VEGF expression levels in ACC(P 0.05);cases with metastasis higher than that of non-metastasis;the cases with neural-invading is higher than that of non-neural-invading cases;the form of vesssels of normal salivary gland tissue and pleomorphic adenoma mainly were expansive blood sinus,and that of ACC were slim bud.Conclusions The expression of VEGF,microvessel density play an important role in the clinicopathological characters of salivary adenoid cystic carcinoma.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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