Title: Expression of extracellular matrix metalloproteinase inducer and microvessel density detection in adenoid cystic carcinoma.
Abstract: Objective:To detect the expression of EMMPRIN and Microvessel Density(MVD)and explore the mecha-nism of EMMPRIN and MVD in the invasion of adenoid cystic carcinoma(ACC). Method:The expression of EMMPRIN and MVD were examined in 33 cases of adenoid cystic carcinoma(ACC)as well as 28 cases of pleomorphic adenoma(PA) as comparison control by immunochemistry SP method. SPSS 10.0 software package was used for chi-square test and t-test.Result:The positive rate of EMMPRIN expression PA and ACC was 53.71% and 90.91% respectively(P0.05). The MVD of ACC was significantly higher than that in PA. No significant difference was found between the group of neural-invading and non-neural-invading on MVD and positive rate of EMMPRIN expression in ACC. Conclusion:Invading behavior of ACC is related to the expression of EMMPRIN and Microvessel Density. The mechanism of EMMPRIN maybe stimulate MMPs production and angionenesis.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot