Title: Clinical effects of ulinastatin in patients with severe burn sepsis
Abstract: Aim To analyze the efficiency of ulinastatin(UTI)in patients with severe burn sepsis syndrome.Methods 62 patients with severe burn sepsis syndrome were randomly divided into treatment group(n=31)and control group(n=31).In the treatment group,patients had Ulinastatin 400 000 IU twice every day for 7 days.The classical treatment including early resuscitation,antibiotic therapy,mechanical ventilation therapy and blood purification was given to two groups.Temperature,respiration,heart rate and white blood cell,neutrocyte percent,the mortality rate on 28 days and other plasma biochemistry indexes were determined before the treatment and after the treatment.Results After the treatment,the levels of temperature,respiration,heart rate and white blood cell,neutrocyte percent were significantly decreased in two groups(P0.05),but the decreases of the treatment group were more marked(P0.05),The ratio and index of oxygen increased.Plasma alanine amino transferase,aspartate amino transferase,blood ureanitrogen,lactate dehydrogenase and MB isoenzyme of creatine kinase were decreased in two groups after the treatment(P0.05),but the decreases of all these plasma biochemistria indexes were more marked in UTI group(P0.05).The treatment group has lower mortality rate on 28 days(P0.05).Conclusion UTI has beneficial effects in patients with severe burn sepsis syndrome.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 2
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