Title: The Effect of Coptis Decoction on Insulin-dependent Diabetic Models of Mice
Abstract: Objective:To research the effect of Coptis decoction on repair function of the islets in mice,and to explore the herbs in the treatment of high blood glucose and preliminary mechanism of action in order to provide experimental basis for clinical application.Method:Use alloxan to make hyperglycemia models,observe the effect of Coptis decoction on insulin-dependent diabetic models in terms of body weight,blood glucose,islet B cell morphology.Result:Coptis decoction could lower blood glucose of model group and effectively control weight loss in a dose dependent manner,and in the 7th,14th day Coptis decoction high dose group and model group were significantly different(P0.05),western medicine(metformin) compared with model group,there was a significant difference(P0.01).Pathological:Coptis Decoction group of islet B cell morphology was better than those in model group and western medicine group and in a dose dependent manner.Conclusion:Coptis decoction can significantly reduce blood glucose of the insulin-dependent diabetic mice,and it can effectively control weight loss of model group,but the short-term effects are not as good as metformin.And it repairs islet B cell morphology significantly.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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