Title: Expression and clinical significance of Wnt-1 and Smad4 in colorectal carcinoma
Abstract: Objective To observe the expression of Wnt-1 and Smad4 in colorectal carcinoma and their clinical significance.Methods Immunohistochemistry staining was used to detect the expression of Wnt-1 and Smad4 in 51cases of colorectal carcinoma.Results ①The expression of Wnt-1 in colorectal carcinoma was higher than expression in the normal tissue(P0.05).The expression of Smad4 in colorectal carcinoma was lower than expression in the normal tissue(P0.05).②The expression of Wnt-1 in colorectal carcinoma was not correlated to age and sex of patients,Dukes stage and lymph node of metastasis of colorectal carcinoma(P0.05),except histological grading and pathological types of patients(P0.05).③The expression of Smad4 in colorectal carcinoma was not correlated to age and sex of patients,histological grading of colorectal carcinoma(P0.05),except Dukes stage,lymph node of metastasis and pathological types of patients(P0.05).④The combined expression of Wnt-1 and Smad4 in colorectal carcinoma was correlated to histological grading of patients(P0.05).Conclusion Wnt-1 and Smad4 may be associated with carcinogenesis,biological behavior and prognosis of colorectal cancer.The two factors may be used as important biological markers in colorectal cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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