Title: Clinical observation on treatment for postoperative gastric cancer by ginsenoside Rg3 combined with chemotherapy
Abstract: The objective of this study was to observe the effects of treatment on postoperative gastric cancer by ginsenoside Rg3 combined with chemotherapy.A total of 96 patients with advanced gastric cancer were randomly divided into treatment group(56 cases)and control group(40 cases).All patients were treated with ELFP or EAP chemotherapy after 2 weeks of surgery.Patients in the treatment group took ginsenoside Rg3(shenyi capsules)20 mg,2 times a day.Six courses of treatment were completed.Objective efficacy,serum VEGF level and CD3,CD4,CD4/CD8,T lymphocyte transformation rate and other changes in immune parameters were observed in all patients.The total effective rate in the treatment group was 69.6%,significantly higher than 47.5% in the control group(P0.05).Serum VEGF decreased 39.5% in patients of the treatment group after treatment(P0.01),significantly lower than that in the control group after treatment(P0.05).CD3,CD4,CD4/CD8 and T lymphocyte transformation rate in treatment group were significantly increased than that before treatment(P0.05),while which were significantly decreased in the control group than that before treatment(P0.05).In conclusion,ginsenoside Rg3 can improve the chemotherapy efficacy in patients with advanced gastric cancer,probably through inhibiting tumor angiogenesis and enhancing immune ability and so on.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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