Title: Impact of Compound Matrine Injection on Clinical Efficacy and Immune Functions among Breast Carcinoma Patients Undergoing Postoperative Chemotherapy
Abstract: Objective To evaluate the effects of compound matrine injection on immune functions and clinical observations in patients with breast cancer undergoing postoperative chemotherapy.Methods Sixty-eight patients with breast cancer undergoing chemotherapy after surgery were randomly divided into 2 groups:the treatment group and the control group.TA chemotherapy was performed in both groups for 6 cycles(21 days/cycle) one week after surgery,with the treatment group received compound matrine injection at the same time.Blood routine test and detection of immunoglobulins,T cell subsets,and IL-4,IL-10 levels were carried out both one day before and one week after chemotherapy.Results Number of white blood cells in the treatment group((5.56±1.78)×109/L) was higher than that in the control group((3.51±1.56)×109/L) with statistical significance(P0.05).Percentages of CD+8 and CD+4 T lymphocytes in the treatment group were significantly higher((39.41±2.34) % and(40.12±1.77)%) than those in the control group((30.14±1.51)% and(25.45±1.41)%)(P0.001).Levels of IgG,IgA and IgM in the treatment group were significantly lower than those in the control group(P0.01).Plasma levels of IL-4 and IL-10 were obviously higher in the treatment group than that in the control group(P0.05).Conclusion Compound matrine injection exhibits the effects of decreasing the toxicity of chemotherapy drugs,increasing white blood cells and enhancing the immune functions in patients with breast cancer undergoing postoperative chemotherapy.Compound matrine injection may improve the life quality of the patients and ensure successful chemotherapy.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 2
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