Title: Influence of Huazhuojiedu compound on serum vascular endothelial growth factor and cyclooxygenase-2 in advanced gastric cancer
Abstract: Objective To investigate influence of Huazhuojiedu compound on serum vascular endothelial growth factor and cyclooxygenase-2(COX-2) in advanced gastric cancer.Methods 66 patients with advanced gastric cancer were randomly divided into two groups.Patients in control group were treated by FOLFOX4.Patients in treatment group were treated by combination of FOLFOX4 and Huazhuojiedu compound,one dose a day.The therapeutic course was 14 days in two groups.The effects and the quality of life were observed,and the levels of serum VEGF and COX-2 were detected in two groups before treatment and after 2 and 4 courses of treatment.Results The effective rate in treatment group(72.22%) was higher than that in control group(46.67%,P0.05).The quality of life in treatment group was obviously higher than that in control group(P0.05).There was obvious difference between before treatment and after 2 courses of treatment on VEGF and COX-2 in two groups(P0.05).There was obvious difference between after 2 courses and 4 courses of treatment on VEGF and COX-2 in two groups(P0.05).There was obvious difference between two groups on VEGF and COX-2 after 4 courses of treatment(P0.05).Conclusion Huazhuojiedu compound combined with chemotherapy can improve therapeutic effect,improve patients' quality of life,and can significantly reduce the gastric serum levels of VEGF and COX-2.Huazhuojiedu compound has a good effect on gastric cancer,may inhibit tumor angiogenesis factor to treat gastric cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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