Title: Experimental Study on Effect of Zhiyanxiao Decoction in Prevention and Treatment of Nonalcohlic Steatohepatitis in Rats
Abstract: Objective:To study the mechanism of Zhiyanxiao decoction(ZYXD)in prevention and treatment of nonalcoholic steatohepatitis(NASH)in rats.Methods:NASH model rats formed by high cholesterol forage feeding were randomly divided into the model group and two ZYXD groups treated with low and high dose of ZYXD(20g/kg and 10g/kg).A group of normal rats was set up for control.Twenty-fourth weeks later,the liver function(ALT,AST),triglyceride(TG),total cholesterol(CHOL)and lipid peroxide were measured,and the pathological alterations of their liver tissues were left to make homogenate and used to measure the content of superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA)and hydroxyproline(Hyp).Results:As compared with the model group,ALT and AST,TG,CHOL,MDA,Hyp were lower,the high density lipoprotein-cholesterol and the activities of SOD,GSH content were higher and the pathological improvement of their liver tissues were especially obvious in the ZYXD groups.Conclusion:ZYXD can obviously ameliorate liver function,lower serum lipid and anti lipid peroxidation.It has certain effect in prevention and treatment of NASH.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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