Title: An Influence of Folic Acid on the Asymmetric Dimethylarginine and Homocysteine of the Patients with Coronary Heart Disease
Abstract: Objective To observe the influence of folic acid on asymmetric dimethylarginine(ADMA) and homocysteine(Hcy) of the patients with coronary heart disease. Methods The ADMA, Hcy, VB12, folic acid, total cholesterol, triglycerides, glucose were measured in serum of 36 cases with coronary heart disease who were given folic acid 5 mg three times a day(folic acid group), 34 cases with coronary heart disease who were not given folic acid (non-folic acid group) and 22 healthy subjects(control group). Results After six months in folic acid group the level of folic acid increased from (8.26±3.03) μg/L to (12.88±7.25) μg/L,Hcy from (32.91±16.06)μmol/L to (23.55±6.01)μmol/L,respectively(P0.05)and ADMA and VB12 were not significantly different(P0.05)compared with those before supplement. Conclusion Supplemental folic acid may increase the serum level of folic acid and improve hyperhomocysteineamia and have no effects on levels of ADMA of the patients with coronary heart disease.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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