Title: Correlative study on plasma homocysteine and serum folic acid,vitamin B_(12) in coronary heart disease
Abstract: Objective To investigate if hyperhomocysteinemia is an independent risk factor associated with coronary heart disease(CHD) and to explore relationship between the levels of plasma homocysteine(Hcy) and serum folic acid,vitamin B12,and their changes in patients with CHD.Methods Plasma Hcy concentrations were measured by fluorescence polarization immunoassays(FPIA),and serum folic acid and vitamin B12 concentrations were measured by chemiluminescent immunoassay(CLIA) respectively in 123 patients with CHD and 101 normal control subjects.Results Plasma Hcy concentrations of patients with CHD were higher than that in controls(P0.01),and serum folic acid concentrations were lower than that in normal controls(P0.01).There were no significant difference between two groups(P0.05) in Serum vitamin B12 concentrations.Logistic-regression analysis indicated that Hcy was an independent risk factor for CHD. The relative risk of hyperhomocysteinemia for CHD was 1.238(95% confidence interval,1.109 to 1.381,P=0.000).The frequency of the hyperhomocysteinemia in CHD cases was 36.59%,which was significantly higher than that in control subjects(9.90%,P0.01).Negative correlation was found between Hcy and folic acid,vitamin B12(P=0.000) in CHD groups.Conclusion Hyperhomocysteinemia is an independent risk factor for CHD.There were negative correlation between the levels of Hcy and serum folic acid,vitamin B12.Determination of serum folic acid and vitamin B12 can provide evidence for diagnosis of CHD.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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