Title: Study of the variation of the expression of CD44v6 in human colorectal carcinoma
Abstract: Objective In the present study,CD44v6 was stained immunohistochemically in 63 colorectal cancer tissues to assess significance of CD44v6 in the carcinogenesis and progression of colorectal carcinoma.Methods Study the variation of the expression of CD44v6 in different stage of human colorectal carcinoma by HE and immunohistochemistry.Results None of the normal colonocytes showed an expression of CD44v6.CD44v6 expression was very strong in 24,moderate in 13,and negative in 26 tumor tissues.A negative or moderate expression of CD44v6 was significantly associated with a larger tumor size(P0.05)1and invasion through the bowel wall(P0.01).There was no correlation between the expression of CD44v6 and gross type,histologic differentiation,lymph nodeinvolvement,liver metastasis,and clinical stage of the disease.Conclusion The present study showed that the expression of CD44v6 was characteristic of neoplastic changes in the colonocytes and that a diminished expression of CD44v6 was associated with the penetration of colorectal cancer through the bowel wall,but not with either lymph node or distant metastasis.Overexpression of CD44v6 is a useful predictor of prognostic marker in patients with colorectal carcinomas.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot