Title: Effect of Bufei decoction on neurotransmitters in enteric nervous system of rats with Lung-Qi deficiency
Abstract: [Objective]To investigate the alteration of substance P(SP),vasoactive intestinal polypeptide(VIP)and nitric oxide(NO)in rat models with Lung-Qi deficiency and evaluate their roles in the pathophysiology of abnormal intestinal motility.[Methods]Thirty Wistar rats were randomized into blank control group(control group),Lung-Qi deficiency model group(model group)and Bufei decoction group(treatment group),20 rats in each group.Rats in the model group and the treatment group were administered intragastrically with distilled water and Bufei decoction,respectively,everyday after modeling.Radio-immunoasay was used to examine the level of plasma VIP;nitrate reductase mothod was performed to detect the content of serum NO;and non-equilibrium method was used to measure the expression of SP in the colon.[Results]The levels of VIP and NO in the model group were significantly higher than those in the control group(P0.01).SP content was decreased significantly compared to the control group.VIP and NO in the treatment group decreased significantly,while SP content increased significantly after the treatment(P0.05).[Conclusion]Abnormal intestinal motility of rat models with Lung-Qi deficiency was mediated by neurotransmitters(excitability/inhibition)secreted by enteric nervous system.Bufei decoction is effective to improve intestinal motility through regulation of neurotrans mitters.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 1
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