Title: The intervention of Maimendong Decoction on DA,NE and 5-HT of hypothalamus and pathological lesion in pulmonary during pulmonary fibrosis formation phase of rats
Abstract: Objective To understand the intervention mechanism of Maimendong Decoction to pulmonary on fibrosis formation stage.Methods The common female Wistar rats were randomly divided into control group,model group,and Maimendong Decoction group.The model was induced by injecting Pingyangmyci except control group.Drugs were used after 14 days in Maimendong Decoction group and all rats were executed after 28 days.Then lung pathology examination were applied and the contents of DA,NE and 5-HT in hypothalamus in all groups were compared.Results The pulmonary fibrosis stage was far higher in the model group than that in the control group(P 0.05) and the stage was far lower in Maimendong Decoction group than that in the model group(P 0.05).The contents of NE,DA and 5-HT in hypothalamus were higher in model group than that in control group(P 0.05) and the contents were lower in Maimendong Decoction group(P 0.05) than that in model group.Conclusion Maimendong Decoction has the function of restraining contents of NE,DA and 5-HT in hypothalamus and reducing pulmonary pathological changes.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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