Title: A comparative study of curative effects of Metoprolol and Enalapril on ventricular arrhythmia in patients with congestive heart failure of coronary heart disease
Abstract: Objective To observe and compare the therapeutic effects of metoprolol and enalapril on ventricular arrhythmia (VA)in patients with congestive heart failure(CHF) of coronary heart disease Methods Forty-two patients of ventricular arrhythmia with congestive heart failure of coronary heart disease (NYHAⅢ-Ⅳ)under conventional therapy were random divided into two groups given metoprolol (12.5-100mg/d)or enalapril (2.5-20mg/d)for 16 weeks. Before and after treatment VA was recorded by 24-hour ambulatory electrocardiographic monitoring and cardiac function was estimated by clinical symptoms and signs.Results After treatment the total incidence of VA in24h reduced by 41.4%and17.1%(P0.01)in the metoprolol and enalapril groups,respectively.The incidences of complex VA and ventricular tachycardia were reduced by 64.4% and 66.7%,respectively in the metoprolol group,and only reduced by 15.3%and 12.5%,respectively in the enalapril group.Between two groups there was significant difference (all, P0.01).The improvement of cardiac function was similar in both groups.Conclusion Both metoprolol and enalapril could good improve cardiac function,but metoprolol could also reduce the incidence of high class VA patiets with CHF of coronary heart disease.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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