Title: Assessment of Myocardial Blood Flow after Infarction with MCE and MRI (An Experimental Study)
Abstract: Purpose To study the value of myocardial contrast echocardiography (MCE) and magnetic resonance imaging (MRI) in the diagnosis of residual flow after infarction. Methods Seven dogs were given ligation of left anterior descending branch to make the pathologic models of acute myocardial infarction (AMI). MCE was performed in vivo dog hearts and perfusion MRI was performed in isolated hearts. Ischemic and infarcted regions were defined as Even's blue and 2,3,5 triphenyltetrazolium chloride (TTC) negative regions respectively. Myocardial blood flow was measured with radioactive microspheres( 99 Tc m MAA). The average width and the volume density of myocardial microvessels were determined and calculated with stereology and immunohistochemistry. Results The MCE intensity in normal regions was 53.23±6.14, in ischemic regions was 23.67±6.14, and in farcted regions was 4.32±4.11. A·β measured by MCE and the MBF measured by 99 Tc m MAA showed high correlation. The time intensity curves of MCE and perfusion MRI in ischemic and infarcted regions showed more consistency. The width and volume density of myocardial microvessels in ischemic and infarcted regions were reduced significantly than that in normal regions. Conclusion MCE and contrast perfusion MRI can determine the residual blood flow and the injury degree of myocardial microvessels after acute myocardial infarction.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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