Title: Identification of myocardial risk area and infarct size by intermittent harmonic myocardial contrast echocardiography
Abstract: Objective Myocardial contrast echocardiography (MCE) allows the possibility to detect myocardial perfusion in vivo.To assessed its accuracy in identifying myocardial area at risk and infarct size by intermittent harmonic MCE.Methods Anesthetized open chest dogs were classified into two groups:Ischemia and reperfusion group (IR) subjected to 1 hour of left descending coronary artery (LDA) occlusion followed by 2 h of reperfusion while ischemic preconditioning group (IP) was given to 5 min ischemia and 5 min reperfusion for 4 times before 1 h of occlusion and 2 h of reperfusion.Intermittent harmonic MCE using intravenous injection of contrast agent C 3F 8 was assessed at 2 h after reperfusion in identifying myocardial area at risk and infarct size versus gross pathologic specimens stained with Evan′s bule and triphenyltetrazolium chloride (TTC).Results The area at risk and infarct size and percents of necrotic area determined by intermittent harmonic MCE had a excellent correlation with that by pathologic stain (r= 0.95 , 0.94 and 0.97 ,respectively,P 0.01 ).Conclusions Intermittent harmonic MCE using intravenous C 3F 8 accurately defined myocardial area at risk and infarct size,which may provide a method in vivo for animal experiment and clinical investigation of myocardial ischemia and reperfusion.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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