Title: The effects of fluvastatin on the endothelial function and blood pressure in isolated systolic hypertension
Abstract: Objective:To investigate the effects of choleserol reduction on the endothelial function and blood pressure in normolipidemic patients with isolated systolic hypertension. Methods:in a randomized , double-blinded, cross-over study design,26 patients with stage I ISH received three months of fluvastatin therapy (20mg/day) and three months of placebo treatment. High-resolution ultrasound was used to determine flow-mediated dilation (FMD) in the brachial artery.Results:Flow-mediated dilation was improved after fluvastatin therapy (6.32±0.71vs.2.96±0.32,P0.05). brachial artery systolic blood pressure was lower after fluvastatin therapy (148±2mmHg vs 154±3mmHg,P0.05) and diastolic blood pressure (78±2mmHg vs 81±3 mmHg,P0.05). Conclusion:Fluvastatin may be beneficial in the treatment of normolipidemic patients wish ISH, through an improvement in the large artery endothelial function.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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