Title: The efficacy of fluvastatin to hypertensives without hyperlipemia
Abstract: Objective:To investigate the clinical effect of fluvastatin in hypertensives without hyperlipemia.Methods:Sixty-seven patients with hypertension and normal lipid were randomly divided into a treatment group of 34 patients and a control group of 33 cases.Two groups were given anti-hypertensive drugs.The treatment group received fluvastatin(40 mg/d),and placebo were given instead of real medicine to the control group.Before treatment and after 12 weeks of treatment,checked blood pressure,height,weight,heart rate,blood lipids,liver and kidney function,arterial endothelial function parameters including endothelin-1(ET-1) and nitric oxide(NO),ankle-brachial index(ABI) brachial artery diameter(D) and blood flow speed(V),the main artery elasticity index(C1) and small artery elasticity index(C2),calculated brachial artery diameter change rate(FMD).Results:Compared with the control group,systolic pressure and pulse pressure and ET-1 of the treatment group were significantly reduced.But FMD and NO in the treatment group were significantly higher than that in the control group.Conclusion:Fluvastatin can reduce the systolic and pulse pressure of hypertensives without hyperlipemia.If plus statins to hypertensive with conventional therapy,whose functionality and flexibility of the intravascular can be improved.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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