Title: AN EXPERIMENT ON ARSENIC TRIOXIDE INDUCING DIFFERENTIATION OF GASTRIC CANCER CELL LINES
Abstract:Objective To study whether arsenic trioxide will induce differentiation of gastric cancer cell.Methods Human gastric cancer cell lines SGC7901 and MKN45 were treated with 0.5 μmol arsenic trioxide and...Objective To study whether arsenic trioxide will induce differentiation of gastric cancer cell.Methods Human gastric cancer cell lines SGC7901 and MKN45 were treated with 0.5 μmol arsenic trioxide and cell proliferation ability was observed under flow cytometry assay and gene expression was detected by immunohistohemistry. Results 1.Arsenic trioxide reduced SGC 7901 proliferation rate. 2. Percentage of G 1/G 0 phase cells increased and percentage of S phase cells decreased after 48 hours. 3. Experssion rate of p53 and bel-XL descended. Expression rate of bax ascended and there was no change in bel-2 expression.Conclusion Arsenic trioxide in low concentration can induce differentiation of gastric cancer cells but can not fully inverse its biological property.Read More
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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Cited By Count: 2
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