Title: Therapeutic Effect of Compound Heparin Oral Colon Targeting Capsules on Ulcerative Colitis in Rats
Abstract: OBJECTIVE To investigate the therapeutic effect of compound heparin oral colon targeting capsules on ulcerative colitis(UC) in rats.METHODS Rats were randomly divided into 6 groups by body weight: the model group,normal group,drug-free capsule group,positive control group,low-dose drug group and high-dose drug group.UC in rats was induced by trinitro-benzen-sulfonic acid(TNBS) in the 6 groups except the normal group.Certain doses of medicines were given to the rats by intragastric administration for 12 d.The tissue damages were scored.The microecology of intestinal tract was observed and the activity of MPO was determined.RESULTS Compared to the model group,the tissue damage was improved in the high-dose drug group(P0.01),while the level of MPO decreased(P0.01) obviously.Meanwhile,the number of probiotics in intestinal tract increased while the harmful bacteria were decreased significantly.CONCLUSION Compound heparin oral colon targeting capsules have definite anti-inflammatory effect for TNBS-induced rat colitis,and can improve intestinal microbiota.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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