Title: Effects of Tongxieercaofang on levels of lactic acid and myelo-peroxidase activity in intestinal mucosa of rats with ulcerative colitis
Abstract: Objective To study effects of Tongxieercaofang(TXECF) on levels of lactic acid(LA)and myeloperoxidase(MPO) in intestinal mucosa tissue of rats with ulcerative colitis and research the mechanism of TXECF on ulcerative colitis.Methods ulcerative colitis model was established by immunization and stimulus.50 rats were divided into 5 groups randomly:normal group,model group,TXECF group,TXYF group,BPYCW group.Then we had observed the effect of TXECF on levels of LA and MPO in intestinal mucosa tissue.Results successful model group,LA and MPO in intestinal mucosa tissue were much higher than those of normal group(P0.01,P0.05).Compared with model group,TXECF could decrease LA and MPO in intestinal mucosa tissue(P0.05) significantly.Conclusion It was suggested that TXECF has functions of restraining MPO activity,reducing infiltration of neutrophilic granulocyte and eliminating LA.So it could reduce inflammatory reaction and heal ulcerative colitis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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