Title: Effects of bifidobacterium on intestinal mucosal barrier function and cytokines in rats with ulcerative colitis
Abstract: Objective To explore the effects of bifidobacterium on intestinal mucosal barrier function and cytokines in rats with ulcerative colitis(UC),and provide a basis for treating UC.Methods Rats were treated with dextran sulfacte sodium solution to establish rat model of ulcerative colitis,and then model rats were randomized into three groups.Rats were administrated with bifidobacterium in group A,mesalazine in group B and saline solution in group C by oral gavage.Rats in group D were not given any drugs except saline solution.The activity of myeloperoxidase(MPO),the levels of IL-6,IL-8 and TNF-α were determined,and the pathological changes of intestinal mucosa were evaluated.Results In comparison with group C,colon mucosal damage index(CMDI),myeloperoxidase(MPO) activities and histological scores were significantly decreased in groups A and B after treatment(P0.05),and IL-6,IL-8,TNF-α levels were also significantly reduced(P0.05).There was no significant difference in those parameters between groups A and B(P0.05).Conclusion Bifidobacterium has protective effects on intestinal mucosa of rats with ulcerative colitis by decreasing intestinal permeability and regulating the cytokines.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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