Title: Relationship between Lymphatic Microvessels Density Marked by Monoclonal Antibody D2-40 and Lymph Node Metastasis in Rectal Carcinoma
Abstract: Objective:To investigate the feature of lymphatic microvessels marked by D2-40 in rectal carcinoma as well as its correlations with the lymph node metastasis. Methods: Ninety tissue specimens of the rectal carcinoma and the peritumoral tissue and thirty specimens of adjacent normal bowel tissue were collected.The expression of D2-40 was detected by immunohistochemistry,and lymphatic microvessel density(LMVD)was determined by lymphatic endothelial specific marker D2-40.The correlations between LMVD and the clinicopathological characteristics were analyzed.Results:The mean value of LMVD in the peritumoral tissue was significantly higher than that in the intratumoral tissue(11.3±4.6 vs 5.1±2.1,P0.01).The values of LMVD in rectal cancer intratumoral and peritumoral tissues were significantly higher than those in normal rectal tissue(3.8±2.5,P0.01).There was a positive significant correlation of high LMVD in peritumoral tissue with the infiltration(P0.05),lymph node metastasis,distant metastasis and Dukes stages(P0.01),but it had no significant correlation with the gender and age of patients,the dimension,location and differetion degree of tumors.Conclusion: High LMVD in peritumoral tissues is closely correlated with the lymph node metastasis in rectal carcinoma.The detection of LMVD in peritumoral tissues may be the index which can be used to judge the lymphangiogenesis or lymph node metastasis of tumor.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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