Title: Effects of somatostatin and pituitrin each combined with pantoprazole on variceal bleeding of liver cirrhosis:A randomized controlled trial
Abstract: Objective To explore the curative effects and side reactions of somatostatin and pituitrin each combined with pantoprazole on variceal bleeding of liver cirrhosis. Methods Patients were assigned randomly to the therapeutic group and the control group,and all were given pantoprazole 40 mg intravenous transfusion,two times one day. For the therapeutic group,0.25 mg somatostatin was given intravenous transfusion firstly,then 0.25 mg/h. For the control group,pituitrin was given in 0.2-0.4u/min. Other therapeutic measures were similar. Results The rate of stop bleeding in 48 h was 90.32% in the therapeutic group and 68.75% in the controlled group,and there was significantly difference between two groups (P0.05). Average stop bleeding time was 29.00±16.36 h in the therapeutic group and 38.00±17.58 h in the control group,and there was significantly difference between two groups (P0.05). The adverse effects in the therapeutic group were fewer than those in the control group. Conclusion Combined with pantoprazole,somatostatin was more effective and safe than pituitrin and had fewer adverse effects in the treatment of variceal bleeding of liver cirrhosis,and hence somatostatin combined with pantoprazole is worthy to be extended.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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