Title: Conventional and double dose octreotide for esophageal variceal hemorrhage in patients with liver cirrhosis
Abstract: AIM: To assess the effect of octreotide for esophageal variceal hemorrhage with conventional and double dose. METHODS: Forty-three cirrhotic patients with esophageal variceal hemorrhage (M 28, F 15; 56 a±s 14 a) were divided into conventional dose group and double dose group. Thirty-three patients of conventional dose group received octreotide(at a rate of 25 μg·h -1 intravenous infusion continually) and ten patients of double dose group received that(at a rate of 50 μg·h -1 intravenous infusion continually) followed an initial bolus 100 μg injection. RESULTS: The bleeding control rates of conventional group and double dose group within 24 h were 76%(25/33), 90%(9/10), respectively. There were no significant differences between them (P 0.05). Five patients whose bleeding was not controlled with conventional dose were changed to use double dose and the bleeding was controlled. There were no statistical differences in the bleeding control rates among the Child-Pugh grades(P 0.05). No obvious adverse reactions were observed either in conventional dose group or double dose group. CONCLUSION: Octreotide is an effective and safe drug for esophageal variceal hemorrhage. It can be effective with double dose when the bleeding is not controlled with conventional dose.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot