Title: Determination of Solvent Residue of Acetone in Clarithromycin by Headspace Gas Chromatography
Abstract: A method for the determination of residue of acetone solvent was established using headspace gas chromatography.The solvent used in this determination was DMF,the column used was HP-FFAP(30m×0.25mm,0.25μm), the carrier gas used was nitrogen with split ratio of 1∶60,the injector temperature was 200℃,the detector temperature was 250℃,and the column temperature was programmed in this determination process.Acetone showed a good linear relationship in the range of 0.002—4 g·L~(-1) in sample solution(r=0.9995),recovery rate was 99.2%(RSD=1.9%),and detecting limit was less than 2.0 mg·L~(-1).
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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