Title: Determination of the contents of residual solvents in zileuton by headspace gas chromatography
Abstract: Objective:To establish a headspace gas chromatography for determination of the contents of residual organic solvents in zileuton. Methods: A packed column (10% FFAP+1%H 3PO 3, 183 cm×2 mm) was used with procedual column temperature control. Results: The calibration curves of 5 solvents hexamethylene, ethanol, ethyl acetate, dichloromethane and methyl benzene were linear ( r 0.999 0). The average recovery rates were 95% 105%. The minimal detection limits were 31.00, 63 00, 9.00, 13.00, 8.70 ng for above 5 solvents, respectively. Conclusion: This analytic method is simple, practical and accurate. [
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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