Title: Expression of E-Cad and α-Cat and its Clinical Significance in Breast Cancer
Abstract: Objective To study the expression of E-Cad and α-Cat and its clinical significance in breast cancer.Methods Immunohistochemical method was used to investigate the expression of E-Cad and α-Cat in 77 cases of breast cancer,15 cases of breast fibroadenoma and 15 cases of breast proliferation.Results The positive rates of E-Cad and α-Cat were 55.8%(43/77) and 39.0%(30/77)in breast cancer,which were significantly lower than those in breast fibroadenoma and breast proliferation(P0.05).The expression of E-Cad significantly related with lymph node status and distant metastasis(P0.05).The expression of α-Cat showed a significant relationship with axillary lymph node status(P0.05).Conclusion The expression of E-Cad and α-Cat may play an important role in infiltration and metastasis of breast cancer.It has a significance for the prognosis of the patients with breast cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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