Title: The effects of extracts from Astragalus membranaceue Bge(ABM) on HepG2 cell
Abstract: Objective:To observe the effect of extracts from Astragalus membranaceue Bge(AMB) on HepG2 cell and its molecular mechanism.Methods:HepG2 cells were cultured in 2 groups:control group and AMB group;MTT assay and RT-PCR were used to test the variation of the two groups.Results:Through light microscope,the cell population and parapodium of HepG2 decreased transparently in AMB group compared with the control group,and some cell floated.The expression of the gene p53 raised and Bcl-xl decreased.Conclusion:The extracts of Astragalus membranaceue Bge(AMB) can restrain the growth of HepG2 cell,the mechanism of which may be the activation of p53 and the suppression of Bcl-xl.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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