Title: An Experimental Study on Protective Effects of Non-wound IschemicPostconditioning to Ischemia/Reperfusion Myocardial Injury of Rats
Abstract: Objective: To observe if there would be protective effects of ischemic postconditioning in non wound legs (N WIPTC) on ischemia/reperfusion (I/R) caused mycocardia injury of rats in vivo. Methods: 30 Sprague Dawley rats were divided randomly into four groups and the model of I/R myocardial injury were produced. The influence of N WIPTC on infarction sizes (IS) was measured with Evan’s and TTC dye. The effects of N WIPTC, malondialehyde (MDA) and superoxide dismutase (SOD) on the I/R caused mycocardia injury were tested with biochemistry and immunohistochemistry techniques. Results: Compared with those of I/R group, the IS and the concentration of MDA in plasma of N WIPTC group were lower (P0 01), and the concentration of SOD in plasma of N WIPTC group was higher. Comparing with that of the ischemic preconditioning (IPC) group, the IS and the concentrations of MDA and SOD in plasma were not significantly different between IPC group and N WIPTC group (P0 05). Conclusion: N WIPTC has the same protective effects as IPC through decreasing the IS. The potential mechanism might be decreasing of the injury caused by oxygen free radical and strengthening the action of antioxidization.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot