Title: Expression of pS2 protein and c-erbB-2 in breast cancer and its clinical significance
Abstract:Objective To explore the relationship of pS2 and c-erbB-2 expression in breast cancer with the clinicopathological features,and to evaluate the value of pS2 protein and c-erbB-2 in judgment of the pro...Objective To explore the relationship of pS2 and c-erbB-2 expression in breast cancer with the clinicopathological features,and to evaluate the value of pS2 protein and c-erbB-2 in judgment of the prognosis of breast cancer and the endocrine therapy. Methods Immunhistochemistry was used to detect the pS2 protein and c-erbB-2 expression in 512 patients with breast cancer. The relationships of the positive expression of pS2 and c-erbB-2 with lymphatic metastasis,pathology type,estrogen receptor( ER) and progesterone receptor( PR) were analyzed. Results In 512 patients with breast cancer,the rates of pS2( + ) and c-erbB-2( + + + ) were 40. 62% and 9. 77% ,respectively. The pS2 protein expression was significantly higher in breast cancer patients without lymph node metastasis than that of patients with lymph node metastasis ( χ2 = 69. 896,P 0. 01) ,and also significantly higher in patients with lobular carcinoma than that of patients with invasive ductal carcinoma( χ2 = 136. 265,P 0. 01) . The c-erbB-2 protein expression was significantly higher in invasive ductal carcinoma patients than in patients with lobular carcinoma( χ2 = 8. 926,P 0. 01) ,higher in PR positive patients than that in PR negative patients ( χ2 = 4. 791,P 0. 05) ,and also higher in ER positive patients than that in ER negative patients ( χ2 = 10. 157,P 0. 01) . Conclusion In breast cancer,c-erbB-2 expression and pS2 expression are closely related to the histological type of breast cancer,lymphatic metastasis,ER and PR level. They could be the indicators to estimate the prognosis of breast cancer and select the pretinence adjuvant therapy after operation.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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